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Ingredients

Taurine: occurs naturally in fish and meat and has many fundamental biological roles.  In cells, taurine keeps potassium and magnesium inside the cell, while keeping excessive sodium out.  It is essential for cardiovascular function, skeletal muscle, retina, and the central nervous system.  Taurine has been shown to help people with congestive heart failure by increasing the force and effectiveness of heart-muscle contractions.  (1)



Niacin: is an organic compound and is one of the 20 to 80 essential human nutrients.  Together with nicotinamide it makes up the group known as vitamin B3 complex.  Medication and supplemental niacin are primarily used to treat high blood cholesterol and pellagra (niacin deficiency).  Insufficient niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness.  (2) 

In this formulation, the vasodilation effect of niacin, known as “flushing” is, among other things, leveraged to promote systemic distribution of the other nutrients.

Flushing may range from barely perceptible for 30 minutes in some individuals, to up to two hours in other individuals, particularly those taking other medications that promote vasodilation and blood flow.  Check with your physician if you’re unfamiliar with niacin, or may be sensitive to the vasodilation, increased blood flow and or the acute drop in blood pressure that may be experienced with niacin.  If you’re new to Natural Energy, please consider taking just a half of a lozenge on your first couple of trials, especially if you’re on medications, and until you’re accustomed to the enhancement of blood flow.



L-Alpha Glycerophosphocholine (Alpha-GPC): is a natural choline compound found in the brain.  It is also an acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and other dementias.  Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier and is a biosynthetic precursor of acetylcholine, an important neurotransmitter.  It is a non-prescription drug in most countries, and in the United States it is classified as GRAS (generally recognized as safe).  (3)



Adenosine monophosphate (AMP): is a nucleotide that occurs widely in life in many metabolic processes and as an important precursor of Adenosine Triphosphate (ATP), the energy currency of the cell.

When consumed in metabolic processes, ATP converts to either the di- or monophosphates, respectively ADP and AMP, while other processes regenerate ATP such that the human body recycles its own body weight equivalent in ATP each day.  ATP is also a precursor to DNA and RNA.  (4)



Citric acid: is an intermediate in the citric acid cycle, which occurs in the metabolism of all aerobic organisms.  The citric acid cycle is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP).  (5)



Methylcobalamin: is a form of Vitamin B12.  Methylcobalamin differs from cyanocobalamin which is a synthetic vitamer that releases cyanide into the body in the process of conversion to one of the active forms of Vitamin B12.  Vitamin B12 is a water-soluble vitamin that has a key role in the normal functioning of the brain and nervous system via the synthesis of myelin (myelinogenesis), and in the formation of red blood cells.  It is one of eight B vitamins.  It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism.  No fungi, plants, or animals, including humans, are capable of producing vitamin B12.  Only bacteria and archaea have the enzymes needed for its synthesis.  Some substantial sources of B12 include animal products such as shellfish and meat, fortified food products, and dietary supplements.  Vitamin B12 is the largest and most structurally complicated vitamin.  (6)

In this formulation B12 is, among other things, especially being used in combination with 5-Methyltetrahydrafolic Acid to facilitate the functioning of the methylation cycle.

The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of crucial bodily functions, including: detoxification, immune function, maintaining DNA, and energy production.



L-5-Methyltetrahydrafolic Acid: is the primary biologically active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine.  It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier.  In the cell, L-5-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF).  THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine.  The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.  Preliminary research suggests that L-5-MTHF taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication.  (7)

L-5-MTHF has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.  (7)

In this formulation L-5-methyltetrahydrofolic acid is, among other things, especially being used in combination with Methylcobalamin, B12, to facilitate the functioning of the methylation cycle.

The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of crucial bodily functions, including: detoxification, immune function, maintaining DNA, and energy production.







Inactive Ingredients


Sorbitol: occurs naturally in many fruits, including apples.  It is a sugar substitute and considered a nutritive sweetener.  Sorbitol is often found in mints, lozenges and sugar free gum.  Sorbitol provides some dietary energy: 2.6 kilocalories per gram versus the average 4 kilocalories per gram for carbohydrates.  (8)

Sorbitol helps protect against tooth decay.  Like all polyols, sorbitol is non-cariogenic, meaning it is not metabolized by oral bacteria which break down sugars and starches to release acids that may lead to cavities or the erosion of tooth enamel.



Malic acid: is made by all living organisms, contributes to the pleasantly sour taste of fruits, and is used as a food additive.  (9)



Natural orange flavor: flavor.



Magnesium stearate: is used as an anti-adherent in the manufacture of medical tablets, capsules and powders.  (10)



Silicon Dioxide: Strengthens collagen, cleans teeth and works as a flow agent in mixing.  (11)



Other natural flavors: flavor.



Sucralose: is used in many food and beverage products because it is a no-calorie sweetener that does not promote dental cavities.  It constitutes <1% (0.5%) of Natural Energy.  (12)



Natural vanilla flavor: flavor.



Stearic acid: is one of the most common saturated fatty acids found in nature and is used as a flow agent in tableting.  It constitutes <1%  (0.05% ) of Natural Energy.







​References


1.  https://en.wikipedia.org/wiki/Taurine

2.  https://en.wikipedia.org/wiki/Niacin

3.  https://en.wikipedia.org/wiki/Alpha-GPC

4.  https://en.wikipedia.org/wiki/Adenosine_triphosphate#ATP_recycling

5.  https://en.wikipedia.org/wiki/Citric_acid

6.  https://en.wikipedia.org/wiki/Methylcobalamin

7.  https://en.wikipedia.org/wiki/Levomefolic_acid

8.  https://en.wikipedia.org/wiki/Sorbitol

9.  https://en.wikipedia.org/wiki/Malic_acid

10.  https://en.wikipedia.org/wiki/Magnesium_stearate

11.  https://en.wikipedia.org/wiki/Silicon_dioxide

12.  https://en.wikipedia.org/wiki/Sucralose

  

Stacked Nutrition Designed by a Physician

Stacked Nutrition Designed by a Physician